Innate Immunity to TB: A Druggable Balancing Act
نویسندگان
چکیده
Tobin and colleagues show that both inhibition and excessive production of the inflammatory mediator TNFα impact the pathogenesis of tuberculosis (TB) and the response to therapy. Identifying a critical role for the genetically determined balance between pro- and anti-inflammatory eicosanoids in regulating TNFα levels provides a roadmap to tailored TB treatment based on host genotype.
منابع مشابه
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عنوان ژورنال:
- Cell
دوره 148 شماره
صفحات -
تاریخ انتشار 2012